ABSTRACT
La Enfermedad de Parkinson se inicia generalmente en las personas entre los 50 y 60 años, La mayoría de los pacientes de Parkinson se encuentran en situación de doble vulnerabilidad: vejez y discapacidad. El objetivo del tratamiento es reducir la velocidad de progresión de la enfermedad, controlar los síntomas y los efectos secundarios derivados de los fármacos que se usan para tratarla. La presentación de las alteraciones psiquiátricas se caracteriza por episodios de alucinaciones, trastornos confusionales, trastornos del control de los impulsos, hipersexualidad o Parasomnias, siendo de presentación habitualmente vespertina. Estos pueden evolucionar llegando a cuadros de psicosis, estados confusionales crónicos, ideas delirantes en forma permanente, con alto contenido paranoide, existiendo un gran riesgo de intentos suicidas.
Parkinson's disease usually begins in people between the ages of 50 and 60. Most Parkinson's patients are in a situation of double vulnerability: old age and disability. The goal of treatment is to reduce the rate of progression of the disease, control of the symptoms and side effects derived from the drugs used to treat it. The presentation of the psychiatric alterations is characterized by episodes of hallucinations, confusional disorders, disorders of the control of the impulses, hypersexuality or Parasomnias, being usually of evening presentation. These can evolve into psychosis, chronic confusional states, persistent delusional ideas, with high paranoid content, and there is a high risk of suicide attempts.
Subject(s)
Humans , Male , Middle Aged , Parkinson Disease/complications , Mental Disorders/complications , Mental Disorders/diagnosis , Mental Disorders/drug therapy , Psychotic Disorders/complications , Psychotic Disorders/diagnosis , Psychotic Disorders/drug therapy , Suicide, Attempted , Antipsychotic Agents/therapeutic use , Medical History Taking , Mental Disorders/classificationABSTRACT
A computer-based system that automates sleep studies, including sleep deprivation paradigms, is described. The system allows for total or REM-specific sleep deprivation and is based on a reliable, fast-responding, on-line state detection algorithm linked to a dependable intervention device. Behavioral state detection is achieved by dimension reduction of short-term EEG power spectrum. Interventions are made by serial outputs to servomotors that move a cage with different patterns and variable intensity. The system can adapt itself to individual characteristics and to changes in recording conditions. Customized protocols can be designed by defining the states or stages to be deprived, including scheduling temporal patterns. A detailed analysis of the relevant signals during and after deprivation is readily available. Data is presented from two experimental designs in rats. One consisted of specific REM-sleep short-term deprivation and the other of 10-hour total sleep deprivation. An outline of conceptual and practical considerations involved in the automation of laboratory set-ups oriented to biosignal analysis is provided. Careful monitoring of sleep EEG variables during sleep deprivation suggests peculiarities of brain functioning in that condition. A corollary is that sleep deprivation should not be considered to be merely a forced prolonged wakefulness.
Subject(s)
Animals , Male , Rats , Electroencephalography/methods , Signal Processing, Computer-Assisted , Sleep Deprivation/physiopathology , Sleep, REM/physiology , Electrodes, Implanted , Rats, Sprague-Dawley , Reaction Time , Time FactorsSubject(s)
Humans , Multiple Organ Failure/complications , Shock, Septic/complications , Systemic Inflammatory Response Syndrome/complications , Multiple Organ Failure/diagnosis , Multiple Organ Failure/epidemiology , Multiple Organ Failure/physiopathology , Sepsis/etiology , Shock, Septic/diagnosis , Shock, Septic/physiopathology , Shock, Septic/history , Systemic Inflammatory Response Syndrome/diagnosis , Systemic Inflammatory Response Syndrome/physiopathologyABSTRACT
En 320 preescolares divididos en dos grupos según edad (2 y 3 años, 4 y 5 años), se practicó - en dos muestras seriadas de orina - recuento total y de bacterias Gram negativas, como parte de un programa tendiente a medir la prevalencia de bacteriuria y la influencia de la edad, sexo y condición socioecocncómica sobre ella. En el grupo de 4 y 5 años, la prevalencia de bacteriuria fue similar a la encontrada en niñas de 6 a 15 años. Los recuentos bacterianos > ou = 10**5 fueron más frecuentes en el sexo femenino, no observándose influencia de la condición socioeconómica. Contrariamente, en las niñas de 2 y 3 años y de situación socioeconómica baja, se presentó mayor prevalencia de bacteriuria verdadera. Estos últimos resultados se contraponen con los obtenidos en estudios epidemiológicos anteriores